The Vitiligo is a plural disease often presents after suffering strong impressions or in the presence of a situation of stress. This condition is triggered in genetically predisposed individuals a neural response (neurochemistry) which destroys the melanocytes showed the presence of an excess of free radicals in the areas of depigmentation phase when melanin becomes toxic to the cells that produced them. Taking antioxidant vitamins and minerals are highly recommended to enhance treatment Melagenina Plus.
The toxins are accumulated in the liver and all those bodies responsible for their elimination, and this leads to remain undifferentiated melanocytes in the basal layer as a result of lack of blood flow, leading to the melanocytes lose their functions and remain in the basal cells as undifferentiated (ie no function to produce melanin which becomes progressive depigmentation of the skin), and this coupled with the inability to acquire keratinocytes retain little melanin that is produced. Such injuries are generally amplified when the carrier becomes aware that the majority of medical professionals judge the condition as incurable.
As part of the accumulation of these residues in the liver, the symptoms that arise are often present in these patients, such as headaches, abdominal pain, reluctance, depression, and itching in areas of injury, hearing loss (may be all present as only one of them).
Besides the excess of free radicals (toxins) has, among other sources, excessive sunlight and skin burns.
Has been related to oxidative stress in the pathogenesis of vitiligo. In one study, we examined the levels of superoxide dismutase, glutathione peroxidase, malondialdehyde and nitric oxide in the tissue of 25 patients with generalized vitiligo in 25 cases and controls. These enzymes and compounds involved in the metabolism of eliminating free radicals.
The results revealed a significant increase in the level of superoxide dismutase, glutathione peroxidase and malondialdehyde in patients with generalized vitiligo (P 0.05). We conclude that the imbalance of tissue oxidation-reduction system with production of free radicals is an initial pathogenic event in the degeneration of melanotic vitiligo.
Antioxidants are substances that act to protect cells from destruction by the chain reaction of electrons (cell death) caused by free radicals. Antioxidants are vitamins A, E, C, etc, and in minerals such as zinc, selenium and copper as well as compounds found in fruits and vegetables. The main functions of human skin are:
Vitamin A (retinoids): Normalizes keratinization: decreases sebum production in acne, reverses sun damage and deals, stretch marks and cellulite.
Vitamin D (and anlogs): Regulates the skin’s immune system, regulates epithelial proliferation and promotes differentiation.
Vitamin C: Antioxidant; regulates the synthesis of collagen, formation of the lipid barrier of the stratum corneum, regenerates vitamin E, provides photoprotection (in combination with vitamin E).